Preclinical findings predicting efficacy and side‐effect profile of LY 2940094, an antagonist of nociceptin receptors-Reference-Cited by-同舟云学术

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Preclinical findings predicting efficacy and side‐effect profile of LY 2940094, an antagonist of nociceptin receptors

Published:2016-11-07 Issue:6 Volume:4 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Witkin Jeffrey M.¹,Rorick‐Kehn Linda M.¹,Benvenga Mark J.¹,Adams Benjamin L.¹,Gleason Scott D.¹,Knitowski Karen M.¹,Li Xia¹,Chaney Steven¹,Falcone Julie F.¹,Smith Janice W.²,Foss Julie²,Lloyd Kirsti²,Catlow John T.¹,McKinzie David L.¹,Svensson Kjell A.¹,Barth Vanessa N.¹,Toledo Miguel A.¹³,Diaz Nuria³,Lafuente Celia³,Jiménez Alma³,Benito Alfonso³,Pedregal Conception³,Martínez‐Grau Maria A.³,Post Anke²,Ansonoff Michael A.⁴,Pintar John E.⁴,Statnick Michael A.¹

Affiliation:

1. Lilly Research Laboratories Eli Lilly and Company Indianapolis Indiana

2. Lilly Research Laboratories Eli Lilly and Company Windlesham Surrey United Kingdom

3. Lilly Research Laboratories Eli Lilly and Company Alcobendas Madrid Spain

4. Lilly Research Laboratories Eli Lilly and Company Rutgers‐Robert Wood Johnson Medical School New Brunswick New Jersey

Funder

Eli Lilly and Company

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.275

Reference45 articles.

1. Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

2. The 5-Hydroxytryptamine2A Receptor Antagonist R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat

3. Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?

4. Assessing antidepressant activity in rodents: recent developments and future needs

5. Animal models of anxiety based on classical conditioning: The conditioned emotional response (CER) and the fear-potentiated startle effect

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2. BTRX-246040 Acts Through the Ventrolateral Periaqueductal Gray to Exert Antidepressant-Relevant Actions in Mice;International Journal of Neuropsychopharmacology;2023-06-05

3. In vitro sepsis up‐regulates Nociceptin/Orphanin FQ receptor expression and function on human T‐ but not B‐cells;British Journal of Pharmacology;2023-05-11

4. The effect of SSRIs on fear learning: a systematic review and meta-analysis;Psychopharmacology;2023-02-27

5. Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders;Molecular Brain;2022-11-24

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