mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease

Author:

Wege Anja Kathrin1,Rom‐Jurek Eva‐Maria1,Jank Paul2,Denkert Carsten2,Ugocsai Peter1,Solbach Christine3,Blohmer Jens‐Uwe4,Sinn Bruno4,Mackelenbergh Marion5,Möbus Volker6,Trumpp Andreas7,Marangoni Elisabetta8,Pfarr Nicole9,Irlbeck Christoph1011,Warfsmann Jens1011,Polzer Bernhard1011ORCID,Weber Florian12,Ortmann Olaf1,Loibl Sibylle13,Vladimirova Valentina13,Brockhoff Gero1ORCID

Affiliation:

1. Department of Gynecology and Obstetrics University Medical Center Regensburg Regensburg Germany

2. Institute of Pathology, Philipps‐University Marburg UKGM University Hospital Marburg Marburg Germany

3. Department of Gynecology and Obstetrics University Hospital Frankfurt Frankfurt Germany

4. Breast Cancer Center Charité Universitätsmedizin Berlin Berlin Germany

5. Department of Gynecology and Obstetrics Schleswig‐Holstein University Hospital Kiel Germany

6. Department of Medicine II, Hematology and Oncology Goethe University of Frankfurt Frankfurt Germany

7. Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ‐ZMBH Alliance Institute for Stem Cell Technology and Experimental Medicine (HI‐STEM gGmbH), German Cancer Consortium (DKTK) Heidelberg Germany

8. Department of Translational Research, Institute Curie PSL Research University Paris France

9. Institute of Pathology Technical University Munich Munich Germany

10. Division of Personalized Tumor Therapy Fraunhofer Institute for Toxicology and Experimental Medicine Regensburg Germany

11. Department of Experimental Medicine University of Regensburg Regensburg Germany

12. Institute of Pathology University of Regensburg

13. German Breast Group GBG Forschungs GmbH Neu‐Isenburg Germany

Funder

Deutsche Krebshilfe

Publisher

Wiley

Subject

Cancer Research,Oncology

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