The effect of maraviroc on the pharmacokinetics of digoxin in healthy volunteers

Author:

Vourvahis Manoli1,Fang Juanzhi2,Choo Heng Wee3,Heera Jayvant2

Affiliation:

1. Pfizer Global Research and Development; New York NY USA

2. Pfizer Global Research and Development; Groton CT USA

3. Pfizer Clinical Research Unit; Singapore Singapore

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference29 articles.

1. Food and Drug Administration, Selzentry: highlights of prescribing information 2007 http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022128lbl.pdf

2. European Medicines Agency. Celsentri (maraviroc), European Public Assessment Report 2011 http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000811/human_med_000689.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d124

3. Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects;Abel;Br J Clin Pharmacol.,2008

4. In vitro and in vivo glucuronidation of midazolam in humans;Hyland;Br J Clin Pharmacol.,2009

5. Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T > C polymorphism;Siccardi;Pharmacogenet Genomics.,2010

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