Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA H1047R accompanied with pro-tumorigenic secretome

Author:

Liu Xue-Ling12,Liu Jia-Li1,Xu Yi-Chao1,Zhang Xi1,Wang Yu-Xiang1,Qing Li-Hua1,Guo Wei1,Ding Jian12,Meng Ling-Hua12ORCID

Affiliation:

1. Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Shanghai People's Republic of China

2. University of Chinese Academy of Sciences; Beijing People's Republic of China

Funder

“Personalized Medicines-Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research Program of the Chinese Academy of Sciences, Chinese Academy of Sciences

National Science and Technology Major Project “Key New Drug Creation and Manufacturing Program”, Ministry of Science and Technology of the People's Republic of China

the Fudan-SIMM Joint Research Fund

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cancer Research,Oncology

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