Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations-Reference-Cited by-同舟云学术

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

Published:2016-02-03 Issue:3 Volume:84 Page:383-396
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Bioinformatics
language:en
Short-container-title:Proteins

Author:

Capoferri Luigi¹,Leth Rasmus²,ter Haar Ernst³,Mohanty Arun K.³,Grootenhuis Peter D. J.⁴,Vottero Eduardo¹,Commandeur Jan N. M.¹,Vermeulen Nico P. E.¹,Jørgensen Flemming Steen²,Olsen Lars²,Geerke Daan P.¹

Affiliation:

1. AIMMS Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences; VU University, De Boelelaan 1083; 1081 HV Amsterdam the Netherlands

2. Department of Drug Design and Pharmacology; University of Copenhagen, Universitetsparken 2; DK-2100 Copenhagen Denmark

3. Vertex Pharmaceuticals Incorporated; 50 Northern Avenue Boston, MA 02210

4. Vertex Pharmaceuticals Incorporated; 11010 Torreyana Road San Diego, CA 92121

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.24985/fullpdf

Reference62 articles.