Bilateral Simultaneous Magnetic Resonance–Guided Focused Ultrasound Pallidotomy for Life‐Threatening Status Dystonicus-Reference-Cited by-同舟云学术

Bilateral Simultaneous Magnetic Resonance–Guided Focused Ultrasound Pallidotomy for Life‐Threatening Status Dystonicus

Published:2024-04-19 Issue:8 Volume:39 Page:1408-1412
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Movement Disorders

Author:

Levi Vincenzo¹,Stanziano Mario²,Pinto Carmela³,Zibordi Federica⁴,Fedeli Davide²,Caldiera Valentina²⁵,Cilia Roberto⁶^ORCID,Golfrè Andreasi Nico⁶,Braccia Arianna⁶,Carozzi Carla³,Ciceri Elisa²⁵,Grisoli Marina²,Gemma Marco³,Nazzi Vittoria¹,DiMeco Francesco¹⁷,Eleopra Roberto¹⁷,Zorzi Giovanna⁴^ORCID

Affiliation:

1. Functional Neurosurgery Unit, Neurosurgery Department Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

2. Neuroradiology Unit, Diagnostic and Technology Department Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

3. Intensive Care Unit, Department of Neurosurgery Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

4. Child Neuropsychiatry Movement Disorders Unit, Pediatric Neuroscience Department Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

5. Interventional Neuroradiology Unit, Department of Neurosurgery Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

6. Parkinson and Movement Disorders Unit, Department of Clinical Neurosciences Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

7. Department of Oncology and Hemato‐Oncology University of Milan Milan Italy

Abstract

AbstractBackgroundInvasive treatments like radiofrequency stereotactic lesioning or deep brain stimulation of the globus pallidus internus can resolve drug‐resistant status dystonicus (SD). However, these open procedures are not always feasible in patients with SD.ObjectiveThe aim was to report the safety and efficacy of simultaneous asleep bilateral transcranial magnetic resonance–guided focused ultrasound (MRgFUS) pallidotomy for life‐threatening SD.MethodsWe performed bilateral simultaneous MRgFUS pallidotomy under general anesthesia in 2 young patients with pantothenate kinase–associated neurodegeneration and GNAO1 encephalopathy. Both patients had medically refractory SD and severe comorbidities contraindicating open surgery.ResultsSD resolved at 4 and 12 days after MRgFUS, respectively. Adverse events (intraoperative hypothermia and postoperative facial paralysis) were mild and transient.ConclusionBilateral simultaneous MRgFUS pallidotomy under general anesthesia is safe and may be a valid alternative therapeutic option for fragile patients. Further studies are needed to assess long‐term efficacy of the procedure.

Funder

Ministero della Salute

Publisher

Wiley

Reference13 articles.

1. The changing face of reported status dystonicus – A systematic review

2. Deep Brain Stimulation for Refractory Status Dystonicus in Children: Multicenter Case Series and Systematic Review

3. Deep brain stimulation versus pallidotomy for status dystonicus: a single-center case series

4. Neurosurgical management of non-spastic movement disorders

5. Bilateral Pallidotomy for Dystonia: A Systematic Review