Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model

Author:

Steele John W.123,Brautigam Hannah234,Short Jennifer A.24,Sowa Allison24,Shi Mengxi24,Yadav Aniruddha24,Weaver Christina M.5,Westaway David6,Fraser Paul E.7,St George-Hyslop Peter H.78,Gandy Sam3910,Hof Patrick R.24,Dickstein Dara L.24

Affiliation:

1. Laboratory of Molecular and Cellular Neuroscience; Rockefeller University; New York NY 10065 USA

2. Fishberg Department of Neuroscience; Icahn School of Medicine at Mount Sinai; New York NY 10029 USA

3. Department of Neurology; Icahn School of Medicine at Mount Sinai; New York NY 10029 USA

4. Friedman Brain Institute; Icahn School of Medicine at Mount Sinai; New York NY 10029 USA

5. Department of Mathematics and Computer Science; Franklin and Marshall College; Lancaster PA 17604 USA

6. Centre for Prions and Protein Folding Diseases; University of Alberta; Edmonton AB T6G 2M8 Canada

7. Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics; University of Toronto; Toronto ON M5S 3H2 Canada

8. Department of Clinical Neurosciences; University of Cambridge; Cambridge CB2 0XY UK

9. Department of Psychiatry; Icahn School of Medicine at Mount Sinai; New York NY 10029 USA

10. James J. Peters VA Medical Center; Bronx NY 10468 USA

Funder

National Institutes of Health

Canadian Institutes of Health Research

the Canada Research Chairs

Alberta Innovatives-Health Solutions

the Alberta Prion Research Institute (to D.W.)

Wellcome Trust

Medical Research Council

the Howard Hughes Medical Institute

the Alzheimer Society of Ontario (to P.E.F., P.H.H.)

Publisher

Wiley

Subject

General Neuroscience

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