Recombinant cells in the lung increase with age via de novo recombination events and clonal expansion

Author:

Kimoto Takafumi1,Kay Jennifer E.1ORCID,Li Na23,Engelward Bevin P.1

Affiliation:

1. Department of Biological Engineering; Massachusetts Institute of Technology; Cambridge Massachusetts

2. Department of Microbiology; National University of Singapore; Block MD4 Level 3 Singapore

3. Singapore-MIT Alliance for Research and Technology, Infectious Diseases Interdisciplinary Group; 1 CREATE Way Singapore

Funder

Nitric Oxide Program Project Grant

Center for Environmental Health Sciences

Interdepartmental Biotechnology Training Program, PI: Karl D. Wittrup

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics(clinical),Epidemiology

Reference62 articles.

1. Homologous recombination as a mechanism for genome rearrangements: Environmental and genetic effects;Bishop;Hum Mol Genet,2000

2. Homologous recombination as a mechanism of carcinogenesis;Bishop;Biochim Biophys Acta,2001

3. In vivo mutation assay based on the endogenous Pig-a locus;Bryce;Environ Mol Mutagen,2008

4. Identification of tumorigenic cells in Kras(G12D)-induced lung adenocarcinoma;Cho;Cancer Res,2011

5. A test for neutrality of mutations of the lacZ transgene;Cosentino;Environ Mol Mutagen,1996

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