Determination of Bioavailability and Systemically Available Fractions of Drugs Undergoing Reversible Metabolism: Application to 4-Amino-5-chloro-2-[2- (methylsulfinyl)ethoxy]-/V-[2-(diethylamino)ethyl]benzamide and Its Sulfide and Sulfone Metabolites in Rats-Reference-Cited by-同舟云学术

Determination of Bioavailability and Systemically Available Fractions of Drugs Undergoing Reversible Metabolism: Application to 4-Amino-5-chloro-2-[2- (methylsulfinyl)ethoxy]-/V-[2-(diethylamino)ethyl]benzamide and Its Sulfide and Sulfone Metabolites in Rats

Published:1994-03 Issue:3 Volume:83 Page:386-390
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Kuo Be-Sheng,Poole James C.,Hwang Kin-Kai,Cheng Haiyung

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference20 articles.

1. Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro- 2-[(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide and its sulfide and sulfone metabolites in rats;Kuo;J. Pharm. Sci.,1993

2. A linear model of reversible metabolism and its application to bioavailability assessment;Hwang;J. Pharmacokinet. Biopharm.,1981

3. General method for assessing bioavailability of drugs undergoing reversible metabolism in a linear system;Hwang;J. Pharm. Sci.,1986

4. Disposition and metabolism;Karim;Clin. Pharmacol. Ther.,1976

5. Pharmacokinetics of sulindac;Kwan;Acta. Rheumatol. Belg.,1977

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacokinetics and splenic accumulation of N-acetylamino-3-chloro-N-(2-diethylamino-ethyl) benzamide after a single administration to rats;Biopharmaceutics & Drug Disposition;2004-09-27

2. Preparation and Evaluation of Sulfide Derivatives of the Antibiotic Brefeldin A as Potential Prodrug Candidates with Enhanced Aqueous Solubilities;Journal of Medicinal Chemistry;2001-09-25

3. Design and Synthesis of Brefeldin A Sulfide Derivatives as Prodrug Candidates with Enhanced Aqueous Solubilities;Journal of Medicinal Chemistry;1998-08-01

4. Mean residence time of drugs administered non-instantaneously and undergoing linear tissue distribution and reversible metabolism and linear or non-linear elimination from the central compartment;Biopharmaceutics & Drug Disposition;1995-05