1. Department of Orthopaedic and Trauma Surgery; Campus Biomedico University of Rome; Via Alvaro del Portillo 200 Rome Italy
2. Giovanni XXIII Cancer Research Center-Institute of General Pathology; Catholic University, School of Medicine; Largo Agostino Gemelli, 8 Rome Italy
3. The Centre for Sports and Exercise Medicine Barts and The London School of Medicine and Dentistry; Mile End Hospital; London UK