Anti‐fibrosis attributes: UHPLC‐MS/MS‐based pharmacokinetics profiling of a novel autotaxin inhibitor with excellent in vivo efficacy in rat-Reference-Cited by-同舟云学术

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Anti‐fibrosis attributes: UHPLC‐MS/MS‐based pharmacokinetics profiling of a novel autotaxin inhibitor with excellent in vivo efficacy in rat

Published:2022-01-20 Issue: Volume: Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Wang Hongjin¹^ORCID,Long Tengfei¹,Zhang Hao¹,Li Meng¹,Sun Qi¹,Zhai Xin²,Sun Lixin¹^ORCID

Affiliation:

1. Department of pharmaceutical analysis, School of Pharmacy Shenyang Pharmaceutical University Shenyang China

2. Key Laboratory of Structure‐Based Drug Design and Discovery, Ministry of Education Shenyang Pharmaceutical University Shenyang China

Funder

Shenyang Pharmaceutical University

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.5301

Reference20 articles.

1. An Autotaxin/lysophosphatidic acid/Interleukin‐6 amplification loop drives scleroderma fibrosis;Castelino F. V.;Arthritis & Rheumatology,2016

2. Pharmacokinetic differences of mifepristone between sexes in animals;Chen W.;Journal of Pharmaceutical and Biomedical Analysis,2018

3. Autotaxin‐lysophosphatidic acid Axis blockade improves inflammation by regulating Th17 cell differentiation in DSS‐induced chronic colitis mice;Dong Y. L.;Inflammation,2019

4. Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis;Fransson J.;Molecular Neurobiology,2021

5. Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae);He C. Y.;Journal of Ethnopharmacology,2012

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