Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival

Author:

Dai Wei1234,Liu Hongliang23,Chen Ka23,Xu Xinyuan23,Qian Danwen23,Luo Sheng5,Amos Christopher I.6,Lee Jeffrey E.7,Li Xin8,Nan Hongmei8,Li Chunying4,Wei Qingyi239

Affiliation:

1. Department of Dermatology; Nanfang Hospital, Southern Medical University; Guangzhou Guangdong China

2. Duke Cancer Institute; Duke University Medical Center; Durham North Carolina

3. Department of Medicine; Duke University School of Medicine; Durham North Carolina

4. Department of Dermatology; Xijing Hospital, Fourth Military Medical University; Xi'an Shaanxi China

5. Department of Biostatistics and Bioinformatics; Duke University School of Medicine; Durham North Carolina

6. Department of Medicine, Baylor College of Medicine; Institute for Clinical and Translational Research; Houston Texas

7. Department of Surgical Oncology; The University of Texas M. D. Anderson Cancer Center; Houston Texas

8. Department of Epidemiology; Fairbanks School of Public Health, Indiana University; Indianapolis Indiana

9. Department of Population Health Sciences; Duke University School of Medicine; Durham North Carolina

Funder

National Institutes of Health/National Cancer Institute

National Natural Science Foundation of China

McCarthy Skin Cancer Research Fund

Shaanxi Science and Technology Innovation Team Project

China Postdoctoral Science Foundation

Marit Peterson Fund for Melanoma Research

P30 Cancer Center Support Grant

University of Texas MD Anderson Cancer Center Various Donors Melanoma and Skin Cancers Priority Program Fund

Miriam and Jim Mulva Research Fund

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference42 articles.

1. Cancer statistics, 2018;Siegel;CA Cancer J Clin,2018

2. Melanoma;Schadendorf;Lancet,2018

3. Metabolic rewiring in melanoma;Ratnikov;Oncogene,2017

4. Ketone bodies as signaling metabolites;Newman;Trends Endocrinol Metab,2014

5. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor;Shimazu;Science,2013

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