Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes

Author:

Yan Lisa12,Silva Diane M. Da23,Verma Bhavna2,Gray Andrew24,Brand Heike E.2,Skeate Joseph G.12,Porras Tania B.12,Kanodia Shreya25,Kast W. Martin1236

Affiliation:

1. Department of Molecular Microbiology and Immunology; University of Southern California; Los Angeles California

2. Norris Comprehensive Cancer Center; University of Southern California; Los Angeles California

3. Department of Obstetrics and Gynecology; University of Southern California; Los Angeles California

4. Vali Nanomedical LLC; Los Angeles California

5. Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences; Cedars-Sinai Medical Center; Los Angeles California

6. Department of Urology; University of Southern California; Los Angeles California

Funder

U.S. Department of Defense

National Institutes of Health

Publisher

Wiley

Subject

Urology,Oncology

Reference48 articles.

1. http://seer.cancer.gov/csr/1975_2011/

2. Biology of castration-recurrent prostate cancer;Azzouni;Urol Clin North Am,2012

3. Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells;Zhang;Prostate,2013

4. Recent progress in pharmaceutical therapies for castration-resistant prostate cancer;Yin;Int J Mol Sci,2013

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