Identifying the antiasthmatic target of doxofylline using immobilizedβ2-adrenoceptor based high-performance affinity chromatography and site-directed molecular docking

Author:

Zhang Yajun1,Zeng Kaizhu1,Wang Jing1,Gao Haiyang1,Nan Yefei2,Zheng Xiaohui1

Affiliation:

1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences; Northwest University; Xi'an 710069 China

2. College of Chemistry and Chemical Engineering; Xi'an Shiyou University; Xi'an 710065 China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Research Fund for the Doctorial Program of Higher Education of China

Scientific Research Plan Projects of Shaanxi Education Department

Administration of Traditional Chinese Medicine of Shaanxi Province

Program for Changjiang Scholars and Innovative Research Team in University

Program for Innovative Research Team of Shaanxi Province

Ministry of Science and Technology of the People's Republic of China

Publisher

Wiley

Subject

Molecular Biology,Structural Biology

Reference39 articles.

1. Characterization of beta-adrenergic binding sites on rodent Leydig cells;Anakwe;Biol. Reprod.,1985

2. Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases: characterization of immobilized μ and κ opioid receptors;Beigi;Anal. Chem.,2003

3. Doxofylline, an anti-asthmatic drug lacking affinity for adenosine receptors;Cirillo;Arch. Int. Pharmacodyn. Ther.,1988

4. Adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle;Davies;Cardiovasc. Res.,1996

5. Chronotropic and arrhythmogenic effects of two methylxanthine bronchodilators, doxofylline and theophylline, evaluated by holter monitoring. comparison with experimental in vitro and in vivo results;Dini;Curr. Ther. Res.,1991

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