Assessment of clinical trial protocols for pathology content using the SPIRIT‐Path guidelines highlights areas for improvement

Author:

Robinson Peter1,Bacon Chris M23,Lim Shujing J3,Shaaban Abeer M45,Brierley Daniel6,Lewis Ian7,Harrison David J8,Kendall Timothy J9ORCID,Robinson Max3ORCID

Affiliation:

1. School of Medical Education Newcastle University Newcastle upon Tyne UK

2. Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK

3. Department of Cellular Pathology Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK

4. Department of Histopathology Queen Elizabeth Hospital Birmingham UK

5. Institute of Cancer and Genomic Sciences University of Birmingham Birmingham UK

6. Unit of Oral and Maxillofacial Pathology University of Sheffield Sheffield UK

7. National Cancer Research Institute London UK

8. School of Medicine University of St Andrews St Andrews UK

9. Centre for Inflammation Research University of Edinburgh Edinburgh UK

Funder

Blood Cancer UK

Breast Cancer Now

Cancer Research UK

Chief Scientist Office

Health and Care Research Wales

Medical Research Council Canada

National Cancer Research Institute

Pathological Society of Great Britain and Ireland

Prostate Cancer UK

Public Health Agency

Tenovus

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference50 articles.

1. SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials

2. SPIRIT.Endorsement. [Accessed 20 September 2021]. Available from:https://www.spirit-statement.org/about-spirit/spirit-endorsement/

3. Recommendations for cellular and molecular pathology input into clinical trials: a systematic review and meta‐aggregation

4. Guidelines for cellular and molecular pathology content in clinical trial protocols: the SPIRIT-Path extension

5. [Accessed 12 December 2021]. Available from:https://www.ecmcnetwork.org.uk/

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