Invasive fungal disease in children with solid tumors: An Australian multicenter 10‐year review-Reference-Cited by-同舟云学术

Invasive fungal disease in children with solid tumors: An Australian multicenter 10‐year review

Published:2024-04-28 Issue:7 Volume:71 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Jain Neha¹²^ORCID,Ryan Anne L.¹²,Haeusler Gabrielle M.³⁴⁵⁶⁷,McMullan Brendan J.⁴⁸⁹,Moore Andrew S.¹⁰¹¹,Bartlett Adam W.⁸¹²,Blyth Christopher C.¹³¹⁴¹⁵¹⁶,Kotecha Rishi S.¹²¹⁷^ORCID,Yeoh Daniel K.⁴⁵⁶¹³^ORCID,Clark Julia E.¹⁸¹⁹^ORCID

Affiliation:

1. Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation Perth Children's Hospital Perth Western Australia Australia

2. Telethon Kids Cancer Centre Telethon Kids Institute University of Western Australia Perth Western Australia Australia

3. Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Victoria Australia

4. National Centre for Infections in Cancer Peter MacCallum Cancer Centre Melbourne Victoria Australia

5. Murdoch Children's Research Institute Parkville Victoria Australia

6. Department of Infectious Diseases Peter MacCallum Cancer Centre Melbourne Victoria Australia

7. Department of Infectious Diseases Royal Children's Hospital Parkville Victoria Australia

8. Department of Immunology and Infectious Diseases Sydney Children's Hospital Randwick New South Wales Australia

9. School of Women's and Children's Health UNSW Sydney New South Wales Australia

10. Oncology Service Queensland Children's Hospital Brisbane Queensland Australia

11. Child Health Research Centre The University of Queensland Brisbane Queensland Australia

12. Kirby Institute UNSW Sydney New South Wales Australia

13. Department of Infectious Diseases Perth Children's Hospital Perth Western Australia Australia

14. Department of Microbiology PathWest Laboratory Medicine Nedlands Western Australia Australia

15. Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute University of Western Perth Western Australia Australia

16. School of Medicine University of Western Australia Perth Western Australia Australia

17. Curtin Medical School Curtin University Perth Western Australia Australia

18. Infection Management Service Queensland Children's Hospital Brisbane Queensland Australia

19. School of Clinical Medicine Children's Health Queensland Clinical Unit The University of Queensland Brisbane Queensland Australia

Abstract

AbstractInvasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004–2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7.0%). Candida species comprised 54.8% of implicated pathogens in proven/probable IFD. In children with solid tumors, IFD is rare, and predominantly caused by yeasts.Routine prophylaxis may not be warranted.

Funder

Gilead Sciences

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.31031

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