1. Department of Biological Statistics and Computational Biology; Cornell University; Ithaca New York 14853
2. Weill Institute for Cell and Molecular Biology; Cornell University; Ithaca New York 14853
3. Department of Biomedical Engineering; Cornell University; Ithaca New York 14853
4. Department of Molecular Biology and Genetics; Cornell University; Ithaca New York 14853
5. Institute of Medical Genetics; Cardiff University, Heath Park; Cardiff CF14 4XN UK