Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half-life: Interplay of age and diurnal feeding pattern-Reference-Cited by-同舟云学术

Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half-life: Interplay of age and diurnal feeding pattern

Published:1992-02 Issue:1 Volume:12 Page:7-11
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J. Appl. Toxicol.

Author:

Charuel C.,Comby P.,Monro A. M.

Publisher

Wiley

Subject

Toxicology

Reference15 articles.

1. The alpha 1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.

2. The antihypertensive effects of doxazosin: a clinical overview.

3. The metabolism and kinetics of doxazosin in man, mouse, rat and dog.

4. (personal communication) reports that an i.v. dose of 5 mg kg−1 of doxazosin to male rats aged 9 months gave a VD of 5.4 1 kg−1, and a plasma half-life of 2.1 h; plasma protein binding was similar in rats aged 2 and 12 months and did not vary with drug concentration.

5. Clinical chronopharmacology. In Biological Rhythms and Medicine. Cellular, Metabolic, Physiopathologic and Pharmacologic Aspects, ed. by and , pp. 211–263. Springer-Verlag, New York (1983).

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