Affiliation:
1. School of Food Science and Technology State Key Laboratory of Food Science and Technology National Engineering Laboratory for Cereal Fermentation Technology National Engineering Research Center for Functional Food Jiangnan University Wuxi Jiangsu P. R. China
2. Institute of Food & Nutrition Science and Technology Shandong Engineering Research Center of Food for Special Medical Purpose Key Laboratory of Agro‐Products Processing Technology of Shandong Province Key Laboratory of Novel Food Resources Processing Ministry of Agriculture and Rural Affairs Shandong Academy of Agricultural Sciences Jinan Shandong P. R. China
Abstract
AbstractBrown adipose tissue (BAT) has been reported to possess the potential to ameliorate diet‐induced obesity. However, the molecular mechanism of BAT activation in alleviating obese states remains unclear. This study investigated the physiology and BAT index of high‐fat diet‐induced and normal chow mice after 3 weeks of mild cold treatment. Body weights and lipid accumulations in BAT and white adipose tissue were significantly decreased by cold treatment. Lipidomics analysis showed that chronic cold treatment caused the remodeling of major lipid classes in BAT, especially species and phospholipid content, plus the mitochondrial morphology. Evidence indicated mitochondrial biogenesis and thermogenesis, and all the effects caused by BAT activation were more pronounced in obese mice. Taken together, our study revealed that phospholipid metabolism is the fundamental requirement in the anti‐obesity effect of BAT.
Funder
National Key Research and Development Program of China