Flow cytometry improves the diagnostic value of fine needle aspiration cytology in a spleen with neuroendocrine tumor: A case report

Author:

Hussain Mahreen1ORCID,Rawas Faisal1,Ali Yasir1,Edhayan Gautam2,Lyapichev Kirill A.1ORCID,Nawgiri Ranjana1

Affiliation:

1. Department of Anatomical and Clinical Pathology The University of Texas Medical Branch Galveston Texas USA

2. Department of Radiology The University of Texas Medical Branch Galveston Texas USA

Abstract

AbstractFine needle aspirations are infrequently performed on the spleen due to concerns for hemorrhagic complications. As a result, splenic lesions can be challenging to diagnose given the limited amount of available specimen. Metastasis to the spleen is rare and metastatic neuroendocrine tumors to the spleen are scarce in literature. The diagnosis of splenic lesions from fine needle aspirate entails processing which prolongs the turnaround time, particularly if the cytomorphology is non‐typical and a limited sample can further complicate this process. We describe a case in which flow cytometry performed on fine needle aspiration of a splenic lesion suggested a diagnosis of neuroendocrine neoplasm involving the spleen. Further workup confirmed this diagnosis. Flow cytometry can recognize neuroendocrine tumors involving the spleen in a timely manner so that appropriate immunohistochemistry tests on limited specimens can be performed to aid in their accurate diagnosis.

Publisher

Wiley

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Reference13 articles.

1. “Turnaround Time (TAT)—Biopsies‐Cap.” CMS Measure ID/CMS QCDR ID: CAP 22 Measure Title: Turnaround Time (TAT)—Biopsies American Medical Association.2020https://documents.cap.org/documents/cap-22-turnaround-time-biopsies-2021.pdf

2. CD56 expression of neuroendocrine neoplasms on immunophenotyping by flow cytometry

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