Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation

Author:

Brady Megan L.1,Jacob Tija C.1

Affiliation:

1. Department of Pharmacology and Chemical Biology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania 15261

Funder

Pharmacology and Chemical Biology Department Startup funds

MLB is in part supported by the Whitehall Foundation

NINDS

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Developmental Neuroscience

Reference44 articles.

1. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties;Araujo;J Pharmacol Exp Ther,1999

2. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus;Brady;J Neurosci,2013

3. Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro;Brunig;J Comp Neurol,2002

4. Compartmentalization of GABAergic inhibition by dendritic spines;Chiu;Science,2013

5. alpha5 Subunit-containing GABA(A) receptors form clusters at GABAergic synapses in hippocampal cultures;Christie;Neuroreport,2002

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