Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras -driven lung tumours

Author:

Närhi Katja1,Nagaraj Ashwini S1ORCID,Parri Elina1,Turkki Riku1,van Duijn Petra W2,Hemmes Annabrita1,Lahtela Jenni1,Uotinen Virva1,Mäyränpää Mikko I34,Salmenkivi Kaisa4,Räsänen Jari5,Linder Nina1,Trapman Jan6,Rannikko Antti7,Kallioniemi Olli1,Af Hällström Taija M18,Lundin Johan1,Sommergruber Wolfgang9,Anders Simon110ORCID,Verschuren Emmy W1ORCID

Affiliation:

1. Institute for Molecular Medicine Finland (FIMM), HiLIFE; University of Helsinki; Helsinki Finland

2. Department of Urology, Josephine Nefkens Institute; Erasmus Medical Center; Rotterdam The Netherlands

3. Department of Pathology; University of Helsinki; Helsinki Finland

4. HUSLAB, Division of Pathology; Helsinki University Hospital; Helsinki Finland

5. Heart and Lung Centre, Department of General Thoracic and Oesophageal Surgery; Helsinki University Hospital; Helsinki Finland

6. Department of Pathology, Josephine Nefkens Institute; Erasmus Medical Centre; Rotterdam The Netherlands

7. Department of Urology; Helsinki University Hospital; Helsinki Finland

8. Orion Corporation; Orion Pharma Espoo Finland

9. Department of Lead Discovery; Boehringer Ingelheim RCV GmbH & Co. KG; Vienna Austria

10. Centre for Molecular Biology of the University of Heidelberg (ZMBH); Heidelberg Germany

Funder

Innovative Medicines Initiative Joint Undertaking grant agreement

European Union's Seventh Framework Programme

EFPIA

Tekes

Deutsche Forschungsgemeinschaft

University of Helsinki Doctoral Programme in Biomedicine scholarships

Sigrid Juselius and Orion-Farmos Foundations (EWV)

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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