A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma-Reference-Cited by-同舟云学术

A rapid, simple and reliable HPLC-triple quadrupole tandem mass spectrometer method for a simultaneous quantification of irinotecan and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma

Published:2014-01-23 Issue:7 Volume:28 Page:919-922
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomed. Chromatogr.

Author:

Ahn Gang¹,Park Dong Min¹,Park Jun Won¹,Kim Hyo-Young²,Cho Joo-Youn³,Rhee Su-jin³,Jang In-Jin³,Kim Hark Kyun¹

Affiliation:

1. Biomolecular Function Research Branch; National Cancer Center; 323 Ilsan-ro, Ilsandong-gu Goyang-si Gyeonggi-do 410-769 Republic of Korea

2. Agilent Technologies Korea Ltd; Sinsa 2nd Bldg, 2F, 542 Yeoksam-ro, Gangnam-gu Seoul 135-848 Republic of Korea

3. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine; 103 Daehak-ro, Jongno-gu Seoul 110-799 Korea

Funder

Converging Research Center Program by the Korean Ministry of Science, ICT and Future Planning

National Cancer Center

Proteogenomic Research program by the Korean Ministry of Science, ICT and Future Planning

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference5 articles.

1. Quantification of irinotecan, SN38, and SN38G in human and porcine plasma by ultra high-performance liquid chromatography-tandem mass spectrometry and its application to hepatic chemoembolization;Chen;Journal of Pharmaceutical and Biomedical Analysis,2012

2. A new UPLC-MS/MS method for the determination of irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) in mice: application to plasma and brain pharmacokinetics;Goldwirt;Journal of Pharmaceutical and Biomedical Analysis,2012

3. Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in mice;Guichard;Cancer Chemotherapy and Pharmacology,1998

4. Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives;Ramesh;Biomedical Chromatography,2010

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