Ferumoxytol‐Enhanced 5D Multiphase Steady‐State Imaging Using Rotating Cartesian K‐Space With Low‐Rank Reconstruction for Pediatric Congenital Heart Disease

Abstract

BackgroundThe rotating Cartesian k‐space multiphase steady‐state imaging with contrast (ROCK‐MUSIC) pulse sequence enables acquisition of whole‐heart, cardiac phase‐resolved images in pediatric congenital heart disease (CHD) without reliance on the ventilator gating signal. Multidimensional reconstruction with low rank tensor (LRT) has shown promise for resolving complex cardiorespiratory motion.PurposeTo enhance ROCK‐MUSIC by resolving cardiorespiratory phases using LRT reconstruction and to enable semi‐automatic hyperparameter tuning by developing an image quality scoring model.Study TypeRetrospective.PopulationThirty patients (45% female, age 2 days to 6.7 years) with CHD.Field Strength/Sequence3‐T, four‐dimensional (4D) spoiled gradient recalled echo sequence.AssessmentEigenvector‐based iTerative Self‐consistent Parallel Imaging Reconstruction (ESPIRiT) served as the reference comparison for LRT reconstruction. A 4‐point Likert scale was used for cardiac and vascular image quality scoring based on cardiac chamber definition, lumen signal uniformity, vascular margin clarity, and motion artifact. Ejection fraction and ventricular volumes were assessed in 16 patients. Signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR), and edge sharpness were computed.Statistical TestsIntraclass correlation coefficients, Wilcoxon signed‐rank test, Bland–Altman. A P‐value <0.05 was considered statistically significant.ResultsRelative to ESPIRiT, LRT images received significantly higher cardiac (2.81 ± 0.57 vs. 3.19 ± 0.54) and vascular (2.81 ± 0.60 vs. 3.36 ± 0.53) image quality scores. Image quality scoring with semi‐automated hyperparameter tuning showed strong correlations (R2 = 0.748) among image quality, SNR, and septal sharpness. Comparison of ejection fraction and volumetry derived from ESPIRiT, and LRT showed no significant systematic difference (P = 0.32).Data ConclusionIntegration of low‐rank reconstruction with ROCK‐MUSIC acquisition may be feasible, and semi‐automatic hyperparameter tuning could be effective for generating cardiorespiratory resolved images.Level of Evidence2Technical EfficacyStage 1