Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer

Author:

Schmitt Katrin1,Molfenter Britta1,Laureano Natalia Koerich123,Tawk Bouchra4,Bieg Matthias5,Hostench Xavier Pastor5,Weichenhan Dieter6,Ullrich Nina D.7,Shang Viny1,Richter Daniela8,Stögbauer Fabian9,Schroeder Lea10,Bem Prunes Bianca3,Visioli Fernanda3,Rados Pantelis Varvaki3,Jou Adriana12,Plath Michaela1,Federspil Philippe A.1,Thierauf Julia1,Döscher Johannes11,Weissinger Stephanie E.12,Hoffmann Thomas K.11,Wagner Steffen13ORCID,Wittekindt Claus13,Ishaque Naveed5,Eils Roland5,Klussmann Jens P.14,Holzinger Dana10,Plass Christoph6,Abdollahi Amir4,Freier Kolja15,Weichert Wilko16,Zaoui Karim1ORCID,Hess Jochen12

Affiliation:

1. Department of Otorhinolaryngology, Head and Neck SurgeryHeidelberg University Hospital Heidelberg Germany

2. Molecular Mechanisms of Head and Neck TumorsGerman Cancer Research Center (DKFZ) Heidelberg Germany

3. Oral PathologyFederal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil

4. Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT)Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) Heidelberg Germany

5. Division of Theoretical BioinformaticsGerman Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ‐HIPO) Heidelberg Germany

6. Cancer EpigenomicsGerman Cancer Research Center (DKFZ) Heidelberg Germany

7. Institute of Physiology and Pathophysiology, Division of Cardiovascular PhysiologyHeidelberg University Heidelberg Germany

8. Translational Medical OncologyNational Center for Tumor Diseases (NCT) Dresden, Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany

9. Institute of Pathology, Heidelberg University Hospital Heidelberg Germany

10. Division of Molecular Diagnostics of Oncogenic InfectionsInfection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ) Heidelberg Germany

11. Department of OtorhinolaryngologyHead and Neck Surgery, University Medical Center Ulm Ulm Germany

12. Institute of Pathology, University Hospital Ulm Ulm Germany

13. Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of Giessen Giessen Germany

14. Department of OtorhinolaryngologyHead and Neck Surgery, University of Cologne Cologne Germany

15. Department of Oral and Maxillofacial SurgeryHeidelberg University Hospital Heidelberg Germany

16. Institute of Pathology, Technical University Munich (TUM), and German Cancer Consortium (DKTK) partner site Munich Germany

Publisher

Wiley

Subject

Cancer Research,Oncology

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