An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS

Author:

Borkar Roshan M.12,Bhandi Murali Mohan1,Dubey Ajay P.3,Ganga Reddy V.2,Komirishetty Prashanth4,Nandekar Prajwal P.5,Sangamwar Abhay T.5,Kamal Ahmed2,Banerjee Sanjay K.26,Srinivas R.13

Affiliation:

1. National Centre for Mass Spectrometry; CSIR-Indian Institute of Chemical Technology; Hyderabad 500 007 India

2. Medicinal Chemistry and Pharmacology Division; CSIR-Indian Institute of Chemical Technology; Hyderabad 500 007 India

3. Department of Pharmaceutical Analysis; National Institute of Pharmaceutical Education and Research; Balanagar Hyderabad 500037 India

4. Department of Pharmacology and Toxicology; National Institute of Pharmaceutical Education and Research; Balanagar Hyderabad 500037 India

5. Department of Pharmacoinformatics; National Institute of Pharmaceutical Education and Research; Sector 67, S.A.S. Nagar (Mohali) 160 062 Punjab India

6. Drug Discovery Research Center; Translational Health Science and Technology Institute; Faridabad 121001 India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference41 articles.

1. l-NAME prevents in vivo the inactivation but not the down-regulation of hepatic cytochrome P450 caused by an acute inflammatory reaction;Barakat;Life Science,2001

2. Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats;Boralli;Chirality,2009

3. Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MS(n) experiments;Borkar;Biomedical Chromatography,2012

4. Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultrahigh performance liquid chromatography-high resolution mass spectrometry;Borkar;Journal of Pharmaceutical and Biomedical Analysis,2014

5. Influence of chronic renal failure on stereo selective metoprolol metabolism in hypertensive patients;Cerqueira;Journal of Clinical Pharmacology,2005

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