Development of a Physiologically Based Pharmacokinetic Model of Ethionamide in the Pediatric Population by Integrating Flavin-Containing Monooxygenase 3 Maturational Changes Over Time

Author:

Nguyen Phuong Thi Thu12,Parvez Md Masud13,Kim Min Jung1,Ho Lee Jung1,Ahn Sangzin1,Ghim Jong-Lyul14,Shin Jae-Gook14

Affiliation:

1. Department of Pharmacology and PharmacoGenomics Research Center; Inje University College of Medicine; Busan Republic of Korea

2. Faculty of Pharmacy; Hai Phong University of Medicine and Pharmacy; Haiphong Vietnam

3. Leslie Dan Faculty of Pharmacy; University of Toronto; Toronto Canada

4. Department of Clinical Pharmacology; Inje University Busan Paik Hospital; Busan Republic of Korea

Funder

Korea Health Industry Development Institute

Ministry of Health & Welfare, Republic of Korea

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference59 articles.

1. World Health Organization Global tuberculosis report 2017

2. World Health Organization Treatment guidelines for drug-resistant tuberculosis, 2016 Update

3. API TB Consensus Guidelines 2006: management of pulmonary tuberculosis, extra-pulmonary tuberculosis and tuberculosis in special situations;Consensus Guidelines;J Assoc Physicians India,2006

4. Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis;Ettehad;Lancet Infect Dis,2012

5. Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes;Henderson;Toxicol Appl Pharmacol,2008

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