Diffusion time dependency of extracellular diffusion

Author:

Xu Junzhong1234ORCID,Xie Jingping1,Semmineh Natenael B.5,Devan Sean P.1,Jiang Xiaoyu12ORCID,Gore John C.1234

Affiliation:

1. Institute of Imaging Science Vanderbilt University Medical Center Nashville Tennessee USA

2. Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA

3. Department of Biomedical Engineering Vanderbilt University Nashville Tennessee USA

4. Department of Physics and Astronomy Vanderbilt University Nashville Tennessee USA

5. Department of Imaging Research Barrow Neurological Institute Phoenix Arizona USA

Abstract

PurposeTo quantify the variations of the power‐law dependences on diffusion time t or gradient frequency of extracellular water diffusion measured by diffusion MRI (dMRI).MethodsModel cellular systems containing only extracellular water were used to investigate the dependence of , the extracellular diffusion coefficient. Computer simulations used a randomly packed tissue model with realistic intracellular volume fractions and cell sizes. DMRI measurements were performed on samples consisting of liposomes containing heavy water(D2O, deuterium oxide) dispersed in regular water (H2O). was obtained over a broad range (∼1–1000 ms) and then fit power‐law equations and .ResultsBoth simulated and experimental results suggest that no single power‐law adequately describes the behavior of over the range of diffusion times of most interest in practical dMRI. Previous theoretical predictions are accurate over only limited ranges; for example, is valid only for short times, whereas or is valid only for long times but cannot describe other ranges simultaneously. For the specific range of 5–70 ms used in typical human dMRI measurements, matches the data well empirically.ConclusionThe optimal power‐law fit of extracellular diffusion varies with diffusion time. The dependency obtained at short or long limits cannot be applied to typical dMRI measurements in human cancer or liver. It is essential to determine the appropriate diffusion time range when modeling extracellular diffusion in dMRI‐based quantitative microstructural imaging.

Funder

National Institutes of Health

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3