Smoking is associated with hypermethylation of theAPC1A promoter in colorectal cancer: the ColoCare Study

Author:

Barrow Timothy M123ORCID,Klett Hagen134,Toth Reka15,Böhm Jürgen15,Gigic Biljana156,Habermann Nina15,Scherer Dominique157,Schrotz-King Petra15,Skender Stephanie15,Abbenhardt-Martin Clare15,Zielske Lin15,Schneider Martin6,Ulrich Alexis6,Schirmacher Peter18,Herpel Esther18,Brenner Hermann159,Busch Hauke410,Boerries Melanie134,Ulrich Cornelia M1511,Michels Karin B1212

Affiliation:

1. German Cancer Consortium (DKTK); Heidelberg Germany

2. Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center; University of Freiburg; Freiburg Germany

3. German Cancer Research Center (DKFZ); Heidelberg Germany

4. Institute of Molecular Medicine and Cell Research; Faculty of Medicine and Medical Center, University of Freiburg, Freiburg; Germany

5. Division of Preventive Oncology; National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ); Heidelberg Germany

6. Department of Surgical Oncology; University Clinic Heidelberg; Heidelberg Germany

7. Institute of Medical Biometry and Informatics; University of Heidelberg; Heidelberg Germany

8. Department of General Pathology; University Clinic Heidelberg; Heidelberg Germany

9. Division of Clinical Epidemiology and Aging Research; German Cancer Research Center (DKFZ); Heidelberg Germany

10. Lübeck Institute of Experimental Dermatology and Institute of Cardiogenetics; University of Lübeck; Lübeck Germany

11. Population Sciences, Huntsman Cancer Institute; Salt Lake City Utah USA

12. Department of Epidemiology; UCLA Fielding School of Public Health; Los Angeles California USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference50 articles.

1. Smoking and colorectal cancer: a meta-analysis;Botteri;JAMA,2008

2. Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females;Parajuli;Clin Epidemiol,2014

3. Smoking and survival of colorectal cancer patients: systematic review and meta-analysis;Walter;Ann Oncol,2014

4. Tobacco, colorectal cancer, and adenomas: a review of the evidence;Giovannucci;J Natl Cancer Inst,1996

5. Postnatal stability, tissue, and time specific effects of AHRR methylation change in response to maternal smoking in pregnancy;Novakovic;Epigenetics,2014

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