Increased radioresistance via G12S K-Ras by compensatory upregulation of MAPK and PI3K pathways in epithelial cancer

Author:

Affolter Annette,Drigotas Martynas,Fruth Kai,Schmidtmann Irene,Brochhausen Christoph,Mann Wolf J.,Brieger Jürgen

Publisher

Wiley

Subject

Otorhinolaryngology

Reference45 articles.

1. Somatic activation of the K-Ras oncogene causes early onset lung cancer in mice;Johnson;Nature,2001

2. Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines;Bernhard;Cancer Res,2000

3. Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from γ-ray irradiation in NIH3T3 cells;Chang;Cancer Res,2005

4. The Ras radiation resistance pathway;Gupta;Cancer Res,2001

5. Molecular targets for altering radiosensitivity: lessons from Ras as a pre-clinical and clinical model;Cengel;Crit Rev Oncol Hematol,2005

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