Association of the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) Polymorphisms With Risk of Coronary Artery Disease in Iranian Patients

Author:

Karam Zahra Miri1ORCID,Yari Abolfazl12ORCID,Najmadini Atefeh3ORCID,Khorasani Nima Norouzi4,Attari Rezvan5,Jafarinejad‐Farsangi Saeideh6ORCID,Karam Mohammad Ali Miri7,Najafipour Hamid8,Saeidi Kolsoum6ORCID

Affiliation:

1. Department of Medical Genetics, Faculty of Medicine Kerman University of Medical Sciences Kerman Iran

2. Cellular and Molecular Research Center Birjand University of Medical Sciences Birjand Iran

3. Department of Medical Immunology, Faculty of Medicine Kerman University of Medical Sciences Kerman Iran

4. Department of Biology, Faculty of Life Sciences Tehran North Branch, Islamic Azad University Tehran Iran

5. Department of Biology University of Guilan Rasht Iran

6. Physiology Research Center Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman Iran

7. Department of Clinical Biochemistry, Faculty of Medicine Kerman University of Medical Sciences Kerman Iran

8. Cardiovascular Research Center Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman Iran

Abstract

ABSTRACTBackgroundCoronary artery disease (CAD) is a devastating illness and a leading cause of death worldwide, primarily caused by atherosclerosis resulting from a genetic‐environmental interaction. This study aimed to investigate the relationship between the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) polymorphisms, lipid profile parameters, and CAD risk in a southeast Iranian population.MethodsA total of 400 subjects (200 CAD patients with hyperlipidemia and 200 healthy controls) were enrolled in this case–control study. Five selected polymorphisms were genotyped using the polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) technique.ResultsFor all single nucleotide polymorphisms (SNPs), the population under study was in the Hardy–Weinberg equilibrium. The T‐risk allele frequency of rs2228570 was associated with an increased risk of CAD. The TT and CT genotypes of rs2228570 had also been associated with the risk of CAD. Additionally, the TT genotype was associated with higher serum low‐density lipoprotein cholesterol (LDL‐c) and high‐density lipoprotein cholesterol (HDL‐c) levels. The GG genotype of the rs3736234 was associated with higher body mass index (BMI) and triglyceride (TG) levels, and the AA genotype of the rs708272 was associated with higher HDL‐c levels. Based on these findings, we propose that the VDR (rs2228570) polymorphism was associated with serum HDL‐c and LDL‐c levels and may serve as potential risk factors for CAD within the Iranian population. Moreover, rs3736234 and rs708272 influence the concentrations of TG and HDL‐c, respectively.ConclusionThese findings provided insights into the complex interplay between genetic variations, cardiovascular risk, and lipid metabolism.

Funder

Kerman University of Medical Sciences

Publisher

Wiley

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