In vivo evaluation of the lysine‐specific demethylase (KDM1A/LSD1) inhibitor SP‐2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC)-Reference-Cited by-同舟云学术

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In vivo evaluation of the lysine‐specific demethylase (KDM1A/LSD1) inhibitor SP‐2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC)

Published:2021-08-28 Issue:11 Volume:68 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatr Blood Cancer

Author:

Kurmasheva Raushan T.¹^ORCID,Erickson Stephen W.²,Han Ruolan³,Teicher Beverly A.⁴,Smith Malcolm A.⁴^ORCID,Roth Michael⁵,Gorlick Richard⁵,Houghton Peter J.¹

Affiliation:

1. Greehey Children's Cancer Research Institute San Antonio Texas USA

2. RTI International Research Triangle Park North Carolina USA

3. Salarius Pharmaceuticals Salt Lake City Utah USA

4. Cancer Therapy Evaluation Program National Cancer Institute Bethesda Maryland USA

5. Pediatrics, Children's Cancer Hospital The University of Texas MD Anderson Cancer Center Houston Texas USA

Funder

National Cancer Institute

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology, and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.29304

Reference17 articles.

1. Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

2. H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1

3. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

4. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

5. Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

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