ALS biomarkers for therapy development: State of the field and future directions

Author:

Benatar Michael1,Boylan Kevin2,Jeromin Andreas3,Rutkove Seward B.4,Berry James5,Atassi Nazem5,Bruijn Lucie6

Affiliation:

1. Department of Neurology; University of Miami; Miami Florida USA 33136

2. Department of Neurology; Mayo Clinic Jacksonville; Jacksonville Florida USA

3. Iron Horse Diagnostics; Scottsdale Arizona USA

4. Department of Neurology; Beth Israel Deaconess Medical Center; Boston Massachusetts USA

5. Department of Neurology; Massachusetts General Hospital; Boston Massachusetts USA

6. ALS Association; Washington DC USA

Publisher

Wiley

Subject

Physiology (medical),Cellular and Molecular Neuroscience,Neurology (clinical),Physiology

Reference116 articles.

1. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework;Biomarkers Definitions Working Group;Clin Pharmacol Ther,2001

2. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Guidance for industry and FDA staff: qualification process for drug development Tools2014 Washington, DC CDER

3. The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis;Shepheard;PLoS One,2014

4. Biomarkers and surrogate markers: an FDA perspective;Katz;NeuroRx,2004

5. The PRO-ACT database: design, initial analyses, and predictive features;Atassi;Neurology,2014

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