Successful immunosuppressive drug‐free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor <scp>IX</scp>: A case report-Reference-Cited by-同舟云学术

Successful immunosuppressive drug‐free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report

Published:2024-08 Issue:8 Volume:12 Page:
ISSN:2050-0904
Container-title:Clinical Case Reports
language:en
Short-container-title:Clinical Case Reports

Author:

Palomo Bravo Ángeles¹,Prieto Bonilla Rosario¹,Bardan Rebollar Daniel¹,López‐Jaime Francisco José²,Fernández‐Bello Ihosvany²^ORCID

Affiliation:

1. Hematology Service Hospital Regional Universitario Materno‐Infantil de Málaga Málaga Spain

2. Thrombosis and Hemostasis Unit, Hematology Service Hospital Regional Universitario de Málaga Málaga Spain

Abstract

Key Clinical MessageRecommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression‐free immune tolerance induction using very low and slowly increasing doses of a factor IX extended‐half‐life product. Immune tolerance to factor IX based on this protocol merits further study.

Funder

CSL Behring España

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.9312

Reference15 articles.

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4. Factor‐ix inhibitors in hemophilia‐B patients‐their incidence and prospects for development with high‐purity factor‐ix products;Briet E;Blood Coagul Fibrinolysis,1991

5. Gene Mutations and Inhibitor Formation in Patients with Hemophilia B

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