A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells

Author:

Preca Bogdan-Tiberius12,Bajdak Karolina12,Mock Kerstin12,Sundararajan Vignesh123,Pfannstiel Jessica1,Maurer Jochen145,Wellner Ulrich6,Hopt Ulrich T.1,Brummer Tilman789,Brabletz Simone110,Brabletz Thomas10,Stemmler Marc P.110

Affiliation:

1. Department of Visceral Surgery; University Medical Center Freiburg; D-79106 Freiburg Germany

2. Faculty of Biology; Albert-Ludwigs-University Freiburg; Freiburg Germany

3. Spemann Graduate School of Biology and Medicine (SGBM); Albert-Ludwigs-University Freiburg; Germany

4. German Cancer Consortium (DKTK); Heidelberg Germany

5. German Cancer Research Center (DKFZ); Heidelberg Germany

6. Department of Surgery; University Medical Center Schleswig-Holstein, Campus Lübeck; Germany

7. Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg; Germany

8. BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg; Germany

9. Comprehensive Cancer Center Freiburg, University Medical Center Freiburg; Germany

10. Department of Experimental Medicine I; Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg; D-91054 Erlangen Germany

Funder

German Research Foundation

Collaborative Research Centre

Excellence Initiative

German Cancer Aid

Emmy-Noether program of the German Research Foundation

Publisher

Wiley

Subject

Cancer Research,Oncology

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