l ‐lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters-Reference-Cited by-同舟云学术

l ‐lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters

Published:2021-09 Issue:1 Volume:237 Page:934-948
ISSN:0021-9541
Container-title:Journal of Cellular Physiology
language:en
Short-container-title:Journal Cellular Physiology

Author:

Nguyen Khuong T. L.¹²,Chiou Jhih‐Yi³,Liu You‐Chi⁴,Cheng Fang‐Ju¹⁵⁶,Shen Yi‐Cheng²⁷,Chen Chao‐Jung⁸⁹,Tang Chih‐Hsin⁵¹⁰^ORCID,Huang Wei‐Chien¹²⁶¹¹¹²^ORCID,Chen Chia‐Hung⁶¹⁰^ORCID,Tu Chih‐Yen⁶¹⁰^ORCID

Affiliation:

1. Center for Molecular Medicine, Research Center for Cancer Biology China Medical University Hospital Taichung Taiwan

2. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan

3. Stella Matutina Girls’ High School Taichung Taiwan

4. Program in Quantitative Social Science Dartmouth College Hanover New Hampshire USA

5. Graduate Institute of Basic Medical Sciences China Medical University Taichung Taiwan

6. Drug Development Center China Medical University Taichung Taiwan

7. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital Taichung Taiwan

8. Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan

9. Department of Medical Research, Proteomics Core Laboratory China Medical University Hospital Taichung Taiwan

10. School of Medicine China Medical University Taichung Taiwan

11. The PhD Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan

12. Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Funder

China Medical University, Taiwan

China Medical University Hospital

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.30570

Reference52 articles.

1. Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

2. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

3. Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance

4. PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs

5. Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression