Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice

Author:

Outeiro Tiago F.1234ORCID,Kalia Lorraine V.567ORCID,Bezard Erwan89ORCID,Ferrario Juan10ORCID,Lin Chin‐Hsien111213,Salama Mohamed1415,Standaert David G.16,Taiwo Lolade17,Takahashi Ryosuke18ORCID,Vila Miquel192021ORCID,Mollenhauer Brit42122ORCID,Svenningsson Per212324ORCID,

Affiliation:

1. Department of Experimental Neurodegeneration Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen Göttingen Germany

2. Max Planck Institute for Multidisciplinary Sciences Göttingen Germany

3. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Newcastle upon Tyne UK

4. Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Göttingen Germany

5. Krembil Research Institute, Toronto Western Hospital, University Health Network Toronto Canada

6. Division of Neurology, Department of Medicine University of Toronto Toronto Canada

7. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto Toronto Canada

8. Université de Bordeaux, Institut des Maladies Neurodégénératives Bordeaux France

9. Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, Institut des Maladies Neurodégénératives Bordeaux France

10. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Instituto de Biociencias, Biotecnología y Biología traslacional (iB3) and CONICET Buenos Aires Argentina

11. Department of Neurology National Taiwan University Hospital Taipei Taiwan

12. Institute of Molecular Medicine, College of Medicine, National Taiwan University Taipei Taiwan

13. Department of Biomedical Engineering National Taiwan University Taipei Taiwan

14. Institute of Global Health and Human Ecology, The American University in Cairo Cairo Egypt

15. Faculty of Medicine, Mansoura University Dakahleya Egypt

16. Department of Neurology Heersink School of Medicine, University of Alabama at Birmingham Birmingham Alabama USA

17. Department of Neurology University College Hospital Ibadan Nigeria

18. Department of Neurology Kyoto University Graduate School of Medicine Kyoto Japan

19. Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR), Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Autonomous University of Barcelona (UAB) Barcelona Spain

20. Catalan Institution for Research and Advanced Studies (ICREA) Barcelona Spain

21. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network Chevy Chase Maryland USA

22. Paracelsus‐Elena‐Klinik, Kassel, Germany; University Medical Center Goettingen, Institute of Neurology Goettingen Germany

23. Department of Clinical Neuroscience and Neurology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden

24. Department of Basic and Clinical Neuroscience King's College London London UK

Abstract

AbstractBasic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel therapies and to establish the basis for personalized medicine. We conclude the viewpoint by a call to action to further improve interactions between clinician and basic scientists. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Funder

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Wiley

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