Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer

Author:

Boulware Stephen B.1,Christensen Laura A.1,Thames Howard2,Coghlan Lezlee3,Vasquez Karen M.1,Finch Rick A.4

Affiliation:

1. Division of Pharmacology and Toxicology; The University of Texas at Austin; Austin Texas

2. Department of Biostatistics; The University of Texas MD Anderson Cancer Center; Smithville Texas

3. Department of Molecular Carcinogenesis; Science Park; The University of Texas MD Anderson Cancer Center; Smithville Texas

4. Department of Veterinary Sciences; The University of Texas MD Anderson Cancer Center; Bastrop Texas

Funder

National Institutes of Health

University Cancer Fund at the University of Texas MD Anderson Cancer Center

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference41 articles.

1. Effect of 2′,2′-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro;Rockwell;Oncol Res,1992

2. Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event;Huang;Cancer Chemother Pharmacol,1995

3. A census of human cancer genes;Futreal;Nat Rev Cancer,2004

4. Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer;Baselga;Semin Oncol,1999

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