Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation

Author:

Quan Peng1,Mao Tianxin2,Zhang Xiaocui3,Wang Ruosi2,Lei Hui3,Wang Jieqiong3,Liu Wanting3,Dinges David F.4,Jiang Caihong2,Rao Hengyi234ORCID

Affiliation:

1. The First Dongguan Affiliated Hospital, School of Humanities and Management Guangdong Medical University Dongguan China

2. Center for Magnetic Resonance Imaging Research & Key Laboratory of Brain‐Machine Intelligence for Information Behavior (Ministry of Education and Shanghai), School of Business and Management Shanghai International Studies University Shanghai China

3. Center for Functional Neuroimaging, Department of Neurology University of Pennsylvania Philadelphia Pennsylvania USA

4. Chronobiology and Sleep Institute University of Pennsylvania Philadelphia Pennsylvania USA

Abstract

AbstractInsufficient sleep compromises cognitive performance, diminishes vigilance, and disrupts daily functioning in hundreds of millions of people worldwide. Despite extensive research revealing significant variability in vigilance vulnerability to sleep deprivation, the underlying mechanisms of these individual differences remain elusive. Locus coeruleus (LC) plays a crucial role in the regulation of sleep–wake cycles and has emerged as a potential marker for vigilance vulnerability to sleep deprivation. In this study, we investigate whether LC microstructural integrity, assessed by fractional anisotropy (FA) through diffusion tensor imaging (DTI) at baseline before sleep deprivation, can predict impaired psychomotor vigilance test (PVT) performance during sleep deprivation in a cohort of 60 healthy individuals subjected to a rigorously controlled in‐laboratory sleep study. The findings indicate that individuals with high LC FA experience less vigilance impairment from sleep deprivation compared with those with low LC FA. LC FA accounts for 10.8% of the variance in sleep‐deprived PVT lapses. Importantly, the relationship between LC FA and impaired PVT performance during sleep deprivation is anatomically specific, suggesting that LC microstructural integrity may serve as a biomarker for vigilance vulnerability to sleep loss.

Funder

National Natural Science Foundation of China

National Institutes of Health

Publisher

Wiley

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