Activation of <scp>eIF4E</scp> ‐binding‐protein‐1 rescues <scp>mTORC1</scp> ‐induced sarcopenia by expanding lysosomal degradation capacity-Reference-Cited by-同舟云学术

Activation of eIF4E ‐binding‐protein‐1 rescues mTORC1 ‐induced sarcopenia by expanding lysosomal degradation capacity

Published:2022-11-17 Issue:1 Volume:14 Page:198-213
ISSN:2190-5991
Container-title:Journal of Cachexia, Sarcopenia and Muscle
language:en
Short-container-title:J cachexia sarcopenia muscle

Author:

Crombie Elisa M.¹,Kim Seonyoung¹,Adamson Stuart²,Dong Han¹,Lu Tzu‐Chiao³,Wu Yiju¹,Wu Yajun⁴,Levy Yotam⁵,Stimple Nolan²,Lam Wing Moon R.⁶,Hey Hwee Weng D.⁶,Withers Dominic J.⁷⁸,Hsu Ao‐Lin³⁹,Bay Boon Huat⁴,Ochala Julien⁵¹⁰,Tsai Shih‐Yin¹¹¹^ORCID

Affiliation:

1. Department of Physiology, Yong Loo Lin School of Medicine National University of Singapore Singapore

2. Buck Institute for Research on Aging Novato California USA

3. Research Center for Healthy Aging China Medical University Taichung Taiwan

4. Department of Anatomy, Yong Loo Lin School of Medicine National University of Singapore Singapore

5. Centre of Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine King's College London UK

6. Department of Orthopedic Surgery, Yong Loo Lin School of Medicine National University of Singapore Singapore

7. Metabolic Signalling Group Medical Research Council London Institute of Medical Sciences (LMS) London UK

8. Institute of Clinical Sciences (ICS) Faculty of Medicine, Imperial College London London UK

9. Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei Taiwan

10. Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark

11. Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine National University of Singapore Singapore

Funder

National Medical Research Council

China Medical University

Medical Research Council Canada

Publisher

Wiley

Subject

Physiology (medical),Orthopedics and Sports Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcsm.13121

Reference40 articles.

1. Sarcopenia: Tilting the Balance of Protein Homeostasis

2. Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men

3. Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

4. Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion

5. Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

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