Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: exploring the limits of substrate tolerance in a promiscuous enzyme
Author:
Affiliation:
1. Department of Chemistry; The Ohio State University; 100 West 18th Avenue Columbus OH 43210 USA
2. Department of Biochemistry; The Ohio State University; 100 West 18th Avenue Columbus OH 43210 USA
Funder
National Institutes of Health via the Center of Excellence
Publisher
Wiley
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/poc.3002/fullpdf
Reference77 articles.
1. The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
2. Chromogenic and Fluorogenic Assays for the Lactonase Activity of Serum Paraoxonases
3. The 'evolvability' of promiscuous protein functions
4. Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents
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