Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

Author:

Fuchs Bryan C.1,Hoshida Yujin2,Fujii Tsutomu1,Wei Lan1,Yamada Suguru1,Lauwers Gregory Y.3,McGinn Christopher M.4,DePeralta Danielle K.1,Chen Xintong2,Kuroda Toshihiko1,Lanuti Michael4,Schmitt Anthony D.4,Gupta Supriya5,Crenshaw Andrew5,Onofrio Robert5,Taylor Bradley5,Winckler Wendy5,Bardeesy Nabeel6,Caravan Peter7,Golub Todd R.8910,Tanabe Kenneth K.1

Affiliation:

1. Division of Surgical Oncology; Massachusetts General Hospital Cancer Center and Harvard Medical School; Boston MA

2. Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine; Icahn School of Medicine at Mount Sinai; New York NY

3. Department of Pathology; Massachusetts General Hospital Cancer Center and Harvard Medical School; Boston MA

4. Division of Thoracic Surgery; Massachusetts General Hospital Cancer Center and Harvard Medical School; Boston MA

5. Genetic Analysis Platform; Broad Institute; Cambridge MA

6. Department of Medicine; Massachusetts General Hospital Cancer Center and Harvard Medical School; Boston MA

7. A.A. Martinos Center for Biomedical Imaging, Department of Radiology; Massachusetts General Hospital and Harvard Medical School; Charlestown MA

8. Cancer Program; Broad Institute; Cambridge MA

9. Dana-Farber Cancer Institute and Harvard Medical School; Boston MA

10. Howard Hughes Medical Institute; Boston MA

Funder

Mount Sinai School of Medicine, New York, NY

Publisher

Wiley

Subject

Hepatology

Reference37 articles.

1. Global cancer statistics;Jemal;CA Cancer J Clin,2011

2. Hepatocellular carcinoma;El-Serag;N Engl J Med,2011

3. Liver cirrhosis;Schuppan;Lancet,2008

4. Fibrosis-dependent mechanisms of hepatocarcinogenesis;Zhang;Hepatology,2012

5. Expression of epidermal growth factor and its receptor in cirrhotic liver disease;Komuves;J Histochem Cytochem,2000

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