The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100-Reference-Cited by-同舟云学术

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100

Published:2017-12-26 Issue:7 Volume:142 Page:1490-1502
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

De Santo Carmela¹,Booth Sarah¹,Vardon Ashley¹,Cousins Antony²,Tubb Vanessa¹,Perry Tracey³,Noyvert Boris³,Beggs Andrew³,Ng Margaret⁴,Halsey Christina²,Kearns Pamela³,Cheng Paul⁵,Mussai Francis¹^ORCID

Affiliation:

1. Institute of Immunology and Immunotherapy, University of Birmingham; Birmingham United Kingdom

2. Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, College of Medical, Veterinary and Life Sciences, University of Glasgow; United Kingdom

3. Institute of Cancer and Genomic Sciences, University of Birmingham; Birmingham United Kingdom

4. Department of Anatomic Pathology; The Chinese University of Hong Kong; Hong Kong

5. Bio-Cancer Treatment International Ltd; Hong Kong

Funder

Cancer Research UK Glasgow Centre

BSU facilities, Cancer Research UK Beatson Institute

Chief Scientists' Office

William and Elizabeth Davies Foundation

Amber Phillpott Trust, Treating Children with Cancer, the Birmingham Children's Hospital Research Fund

patient and family fundraisers via the University of Birmingham Development and Alumni Relations Team and Cancer Research UK

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference45 articles.

1. The development of targeted new agents to improve the outcome of children with leukemia;Bautista;Expert Opin Drug Discov,2016

2. In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993);Goldstone;Blood,2008

3. Risk of late effects of treatment in children newly diagnosed with standard risk acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study cohort;Essig;Lancet Oncol,2014

4. Biochemical responses of healthy subjects during dietary supplementation with L-arginine;Evans;J Nutr Biochem,2004

5. Arginine metabolism: nitric oxide and beyond;Wu;Biochem J,1998

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