APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline-Reference-Cited by-同舟云学术

APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

Published:2020-01 Issue:1 Volume:6 Page:
ISSN:2352-8737
Container-title:Alzheimer's & Dementia: Translational Research & Clinical Interventions
language:en
Short-container-title:A&D Transl Res & Clin Interv

Author:

Abushakra Susan¹,Porsteinsson Anton P.²,Sabbagh Marwan³,Bracoud Luc⁴,Schaerer Joel⁴,Power Aidan¹,Hey John A.¹,Scott David⁵,Suhy Joyce⁴⁵,Tolar Martin¹,

Affiliation:

1. Alzheon Inc. Framingham Massachusetts USA

2. Alzheimer's Disease Care Research and Education Program University of Rochester Rochester New York USA

3. Cleveland Clinic Lou Ruvo Center for Brain Health & University of Nevada Las Vegas Nevada USA

4. Bioclinica Lyon France

5. Bioclinica Newark California USA

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/trc2.12117

Reference51 articles.

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3. US Dept. of Health and Human Services FDA Draft Guidance for Industry Feb 2018: Early Alzheimer's Disease: Developing Drugs for Treatment.

4. European Medicines Agency Committee for Medicinal Products for Human Use CPMP/EWP/553/95 Rev2. 2018. Guideline on the Clinical Investigation of Medicines for the Treatment of Alzheimer's Disease.

5. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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