Hepatotoxicity mechanisms of isoniazid: A mini-review

Author:

Hassan Hozeifa M.12,Guo Hong-li1,Yousef Bashir A.13,Luyong Zhang145,Zhenzhou Jiang167

Affiliation:

1. Jiangsu Key Laboratory of Drug Screening; China Pharmaceutical University; Nanjing China

2. Department of Pharmacology, Faculty of Pharmacy; University of Gezira; Wad-Medani Sudan

3. Department of Pharmacology, Faculty of Pharmacy; University of Khartoum; Khartoum Sudan

4. Jiangsu Center for Pharmacodynamics Research and Evaluation; China Pharmaceutical University; Nanjing China

5. Jiangsu Key Laboratory of TCM Evaluation and Translational Research; China Pharmaceutical University; Nanjing China

6. Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University); Ministry of Education; Nanjing China

7. State Key Laboratory of Natural Medicines; China Pharmaceutical University; Nanjing China

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

Publisher

Wiley

Subject

Toxicology

Reference95 articles.

1. Isoniazid;Anon;Tuberc.,2008

2. Effects of four Indian medicinal herbs on Isoniazid-Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs;Adhvaryu;World J. Gastroenterol.,2007

3. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role;Aubert;Clin. Res. Hepatol. Gastroenterol.,2011

4. Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells;Bhadauria;Cell. Mol. Biol.,2007

5. Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation;Bhadauria;Toxicol. Mech. Methods,2010

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