In vitro metabolic profile and drug‐drug interaction assessment of secnidazole, a high‐dose 5‐nitroimidazole antibiotic for the treatment of bacterial vaginosis

Author:

Pentikis Helen S.1,Adetoro Nikki2,Kaufman Gregory2

Affiliation:

1. SAJE Consulting Baltimore MD USA

2. Lupin Pharmaceuticals Baltimore MD USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference27 articles.

1. Secnidazole

2. PetrinaM CosentinoL RabeL HillierS.Susceptibility of bacterial vaginosis (BV)‐ associated bacteria to secnidazole metronidazole tinidazole and clindamycin. Presented at: Infectious Diseases Society of Obstetrics and Gynecology Annual Meeting; August 11‐13 Annapolis MD. 2016.

3. A phase 2 randomized, double‐blind, placebo‐controlled study to evaluate the effectiveness and safety of single, oral doses of SYM‐1219, a granule formulation containing 1 and 2 gram doses of secnidazole, for the treatment of women with bacterial vaginosis;Hillier S;Infect Dis Soc Obstet Gynecol.,2015

4. Treatment of Bacterial Vaginosis: A Multicenter, Double-Blind, Double-Dummy, Randomised Phase III Study Comparing Secnidazole and Metronidazole

5. Nitroimidazole drugs-action and resistance mechanisms I. Mechanism of action

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