A Quality-by-Design Study for an Immediate-Release Tablet Platform: Examining the Relative Impact of Active Pharmaceutical Ingredient Properties, Processing Methods, and Excipient Variability on Drug Product Quality Attributes

Author:

Kushner Joseph,Langdon Beth A.,Hicks Ian,Song Daniel,Li Fasheng,Kathiria Lalji,Kane Anil,Ranade Gautam,Agarwal Kam

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference23 articles.

1. Final report on pharmaceutical cGMPs for the 21st centuryA risk—based approach;Food and Drug Administration,2004

2. Food and Drug Adminstration. Quality by Design for ANDAs: An example for immediaterelease dosage forms;Food and Drug Administration,2012

3. Pharmaceutical Quality by Design: Product and process development, understanding, and control;Yu;Pharm Res,2008

4. Functionality and performance of excipients in a quality-by-design world part 2: Excipient variability, QbD and robust formulations;Moreton;Am Pharm Rev,2009

5. Compendial standards and excipient performance in the QbD era: USP excipient performance chapter <1059>;Sheehan;Am Pharm Rev,2011

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