A rare case of heme oxygenase deficiency: A case report and literature review-Reference-Cited by-同舟云学术

A rare case of heme oxygenase deficiency: A case report and literature review

Published:2024-05-23 Issue:6 Volume:12 Page:
ISSN:2050-0904
Container-title:Clinical Case Reports
language:en
Short-container-title:Clinical Case Reports

Author:

Alla Sai Santhosha Mrudula¹,Agarwal Pahel²,Shah Dhruv J.³,Shajahan Waseem Abrar⁴,Ramsundar Rakshna⁵,Alla Deekshitha¹^ORCID,Ravulapalli Madhavi²,Bora Satya⁶,Pillai Sanjay⁷,Bayeh Ruth G.⁸^ORCID,Repalle Uday Kumar⁶,Suhani Fnu⁹

Affiliation:

1. Andhra Medical College Visakhapatnam India

2. Bhaskar Medical College Hyderabad India

3. Massachusetts College of Pharmacy and Health Sciences Boston Massachusetts USA

4. Government Medical College Kozhikode Kozhikode India

5. Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) Chennai India

6. Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation Chinna Avutapalle India

7. MS Ramaiah Medical College Bengaluru India

8. Adama General Hospital and Medical College Nazret Ethiopia

9. Dayanand Medical College and Hospital Ludhiana India

Abstract

Key Clinical MessageHeme oxygenase deficiency, a rare condition disrupting heme metabolism, has only nine reported cases. We present a 3‐year‐old boy with dysmorphic facies, asplenia, and normal bilirubin levels despite ongoing hemolysis. Blood transfusions sustained hemoglobin while IV steroids managed inflammation.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ccr3.8986

Reference20 articles.

1. Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

2. Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology

3. Heme Oxygenase-1 Deficiency and Oxidative Stress: A Review of 9 Independent Human Cases and Animal Models

4. Heme oxygenase-1 deficiency as an extremely rare cause of AA-type renal amyloidosis: Expanding the clinical features and review of the literature

5. Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency