The effect of methylphenidate for giggle incontinence in children

Author:

Svendsen Ann-Kristine Mandoe12ORCID,Kamperis Konstantinos3,Hagstroem Soeren4,Thorsteinsson Kristina Nauheimer5,Arvad Mads12,Borch Luise12

Affiliation:

1. Department of Pediatric and Adolescent Medicine Gødstrup Hospital Herning Denmark

2. NIDO, Centre for Research and Education Gødstrup Hospital Herning Denmark

3. Department of Pediatric and Adolescent Medicine Aarhus University Hospital Aarhus Denmark

4. Department of Pediatric and Adolescent Medicine, Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark

5. Department of Pediatric and Adolescent Medicine Aalborg University Hospital Aalborg Denmark

Abstract

AbstractIntroductionGiggle incontinence (GI) is a rare form of urinary incontinence that occurs during or immediately after laughing due to involuntary and complete bladder emptying. Few studies in the literature report that methylphenidate can be effective in treatment of this condition.ObjectiveThe aim of this study is to characterize children with GI and evaluate their response to methylphenidate, as well as describe treatment duration, dosage of methylphenidate, relapse rates after discontinuation of medication, and side effects.MethodsMedical records and 48‐h frequency‐volume charts from children treated with methylphenidate for GI in the period January 2011–July 2021 were retrospectively analyzed.ResultsEighteen children were diagnosed with GI and fulfilled inclusion criteria. Fifteen patients were included in analysis, as 3 out of 18 children decided not to take the methylphenidate that was prescribed. In total, 14 out of the 15 GI patients treated with methylphenidate experienced clinical effect. All patients included in the study had methylphenidate prescribed in a dose range of 5–20 mg daily. Treatment duration ranged from 30 to 1001 days, with a median of 152 days (IQR 114, 243.5). Ten children experienced complete response and two of those reported symptom relapse after discontinuation of the methylphenidate. Only mild and short‐lasting side effects were reported by two patients.DiscussionOur study demonstrates that methylphenidate is an effective treatment in children diagnosed with GI. Side effects are mild and uncommon.

Publisher

Wiley

Subject

Urology,Neurology (clinical)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Giggle incontinence: a scoping review;Pediatric Research;2024-02-02

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