Change in lipids before onset of dementia, coronary heart disease, and mortality: A 28‐year follow‐up Whitehall II prospective cohort study

Author:

Hassen Céline Ben1,Machado‐Fragua Marcos D1,Landré Benjamin1,Fayosse Aurore1,Dumurgier Julien12,Kivimaki Mika3,Sabia Séverine13,Singh‐Manoux Archana13

Affiliation:

1. Université Paris Cité, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases Paris France

2. Cognitive Neurology Center, Lariboisière – Fernand Widal Hospital, AP‐HP Université Paris Cité Paris France

3. Department of Mental Health of Older People, Faculty of Brain Sciences University College London London UK

Abstract

AbstractINTRODUCTIONThe association of lipids with dementia remains a subject of debate. Using data from 7,672 participants of the Whitehall II prospective cohort study, we examined whether timing of exposure, length of follow‐up, or sex modifies this association.METHODSTwelve markers of lipid levels were measured from fasting blood and eight among them a further five times. We performed time‐to‐event as well as trajectory analyses.RESULTSNo associations were observed in men; in women most lipids were associated with the risk of dementia, but only for events occurring after the first 20 years of follow‐up. Differences in lipid trajectories in men emerged only in the years immediately before diagnosis whereas in women total cholesterol (TC), LDL‐cholesterol (LDL‐C), non‐HDL‐cholesterol (non‐HDL‐C), TC/HDL‐C, and LDL‐C/HDL‐C were higher in midlife among dementia cases before declining progressively.DISCUSSIONAbnormal lipid levels in midlife seem to be associated with a higher risk of dementia in women.

Funder

National Institute on Aging

Academy of Finland

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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